This is a potential replacement for HCG, as the combination of products in EndoTest is gonadarelin, DHEA, and oxytocin. This combination is designed to provide multiple avenues through which to elicit signaling of GnRH from the hypothalamus to the pituitary gland, which in turn releases luteinizing hormone and follicle stimulating hormone.

Oxytocin has been shown to act in the testis through a specific oxytocin receptor and will increase basal testosterone production with no effect on LH stimulated testosterone production. It has been prescribed off-label to increase sociability, and to increase sex drive and sexual function. Oxytocin can also induce anti-stress effects such as reduction in blood pressure and cortisol levels. Additionally it has been shown to promote bone density in women.

DHEA is one of the most abundant steroids circulating in the body, it is a precursor to testosterone, and it has a significant amount of RCT data supporting the association of its use with increased plasma testosterone levels in both genders. DHEA is mainly produced by the adrenal glands and is produced by the conversion of cholesterol. It has been shown to enhance free testosterone levels and it is banned as an anabolic agent by the World Anti-Doping Agency.