Dopamine, norepinephrine, and serotonin neurotransmitters are responsible for balancing energy and are related to depression and obesity. Tesofensine works by increasing the transmission of neurotransmitters in the brain. The neurotransmitter Dopamine release produces the feeling of pleasure and satisfaction in the brain. Tesofensine has also been used for ADHD and stimulant abuse.

When the dopamine level is not balanced, our body may lose its many benefits. Lowered dopamine in the body can result in behavioral changes and dopamine adaptation. Reduced dopamine can alter the brain signals, resulting in glucose intolerance, obesity, and weight gain. Tesofensine prevents the central nervous system from reabsorbing the three neurotransmitters dopamine, serotonin, and noradrenaline. This process results in reducing hunger while increasing resting energy expenditure and fat oxidation. It also modulates the action of dopamine which influences a particular section of the brain to replicate the pleasure sensation of consuming food.